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ASCO 2021丨一文速览黑色素瘤重磅研究

作者:肿瘤瞭望   日期:2021/5/6 16:20:41  浏览量:8081

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编者按:2021年美国临床肿瘤学会(ASCO)年会-虚拟会议将于2021年6月4~8日举行。本次会议设有一个黑色素瘤口头报告的专场,将汇报8项重磅研究。此外,在分子靶向药物和肿瘤生物、免疫治疗等两个创新疗法口头报告专场中,也有2项黑色素瘤的研究。锁定《肿瘤瞭望》,关注ASCO进展!

专场:Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology

时间:星期五,6月4日,11:00 PM - 2:00 AM CST

 

A phase Ib trial of belvarafenib in combination with cobimetinib in patients with advanced solid tumors: Interim results of dose-escalation and patients with NRAS-mutant melanoma of dose-expansion.


belvarafenib联合考比替尼治疗晚期实体瘤患者的Ib期试验:剂量增加和NRAS突变黑色素瘤患者剂量扩展的中期结果


作者:Sang Joon Shin, et al

摘要:3007

专场:Melanoma/Skin Cancers

时间:星期日,6月6日,8:00 PM - 11:00 PM CST



Crossover and rechallenge with pembrolizumab in recurrent patients from the EORTC 1325-MG/Keynote-054 phase 3 trial, pembrolizumab versus placebo after complete resection of high-risk stage III melanoma.


在高危III期黑色素瘤完全切除后帕博利珠单抗对比安慰剂辅助治疗的3期EORTC 1325-MG/Keynote-054试验中,复发患者的交叉和帕博利珠单抗再挑战


作者:Alexander M. Eggermont, et al.摘要号:9500


Final analysis of overall survival (OS) and relapse-free-survival (RFS) in the intergroup S1404 phase III randomized trial comparing either high-dose interferon (HDI) or ipilimumab to pembrolizumab in patients with high-risk resected melanoma.


比较高剂量干扰素或伊匹木单抗与帕博利珠单抗治疗高危已切除黑色素瘤的III期随机试验S1404的最终OS和RFS分析


作者:Kenneth F. Grossmann, et al.


摘要号:9501


Neoadjuvant and adjuvant nivolumab (nivo) with anti-LAG3 antibody relatlimab (rela) for patients (pts) with resectable clinical stage III melanoma.


纳武利尤单抗联合抗LAG3抗体relatlimab新辅助和辅助治疗可切除III期黑素瘤患者


作者:Rodabe N. Amaria, et al.


摘要号:9502


Relatlimab (RELA) plus nivolumab (NIVO) versus NIVO in first-line advanced melanoma: Primary phase III results from RELATIVITY-047 (CA224-047).


Relatlimab联合纳武利尤单抗对比纳武利尤单抗一线治疗晚期黑色素瘤:III期RELATIVITY-047(CA224-047)试验的首次结果


作者:Evan J. Lipson, et al


摘要号:9503


Lenvatinib (len) plus pembrolizumab (pembro) for patients (pts) with advanced melanoma and confirmed progression on a PD-1 or PD-L1 inhibitor: Updated findings of LEAP-004.


仑伐替尼+帕博利珠单抗治疗PD-1/L1抑制剂进展的晚期黑色素瘤患者:LEAP-004的最新研究结果


作者:Ana M. Arance, et al.


摘要号:9504


Lifileucel (LN-144), a cryopreserved autologous tumor infiltrating lymphocyte (TIL) therapy in patients with advanced melanoma: Evaluation of impact of prior anti-PD-1 therapy.


Lifileucel(LN-144),一种冷冻保存的自体肿瘤浸润淋巴细胞(TIL)治疗晚期黑色素瘤:评价既往PD-1治疗的影响


作者:James Larkin, et al.


摘要号:9505


CheckMate 067: 6.5-year outcomes in patients (pts) with advanced melanoma.


CheckMate 067:晚期黑素瘤患者6.5年结局


作者:Jedd D. Wolchok, et al.


摘要号:9506


Five-year overall survival (OS) in COLUMBUS: A randomized phase 3 trial of encorafenib plus binimetinib versus vemurafenib or encorafenib in patients (pts) with BRAF V600-mutant melanoma.


COLUMBUS研究5年OS:康奈非尼+比米替尼对比维莫非你+康奈非尼治疗BRAF V600突变黑色素瘤患者的随机3期试验


作者:Reinhard Dummer, et al.


摘要号:9507


Five-year overall survival from the anti-PD1 brain collaboration (ABC Study): Randomized phase 2 study of nivolumab (nivo) or nivo+ipilimumab (ipi) in patients (pts) with melanoma brain metastases (mets).


抗PD-1脑协作(ABC研究)的5年OS:纳武利尤单抗或纳武利尤单抗+伊匹木单抗治疗黑色素瘤脑转移患者的随机2期研究


作者:Georgina V. Long, et al


摘要号:9508


专场:Developmental Therapeutics—Immunotherapy

时间:星期二,6月8日,3:00 AM - 6:00 AM CST


Preliminary results of a phase II study of alrizomadlin (APG-115), a novel, small-molecule MDM2 inhibitor, in combination with pembrolizumab in patients (pts) with unresectable or metastatic melanoma or advanced solid tumors that have failed immuno-oncologic (I-O) drugs.


新型小分子MDM2抑制剂alrizomadlin(APG-115)联合帕博利珠单抗治疗不可切除/转移性黑色素瘤或肿瘤免疫治疗药物失败晚期实体瘤患者的II期研究初步结果


作者:Anthony W. Tolcher, et al.


摘要号:2506

版面编辑:洪山  责任编辑:李春明

本内容仅供医学专业人士参考


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